Locally invasive, but rarely metastasizing neoplasm derived from basal cells of the epidermis or hair follicles.
Any of the various types of malignant neoplasm derived from epithelial tissue in several sites, occurring more frequently in the skin and large intestine in both sexes, the bronchi, stomach, and prostate gland in men, and the breast and cervix in women. Carcinomas are identified histologically on the basis of invasiveness and the changes that indicate anaplasia, i.e., loss of polarity of nuclei, loss of orderly maturation of cells, variation in the size and shape of cells, hyperchromatism of nuclei, and increase in the nuclear-cytoplasmic ratio.
Not actually a true neoplasm, but a congenital anomaly; proliferation of vascular endothelium leads to a mass that resembles neoplastic tissue. It can occur anywhere in the body but is most frequently noticed in the skin and subcutaneous tissues.
A brown macule resembling a freckle except that the border is usually regular, and microscopic proliferation of rete ridges is present. Scattered solitary nevus cells are seen in the basal cell layer.
A term originally used to depict erosion (as if gnawed) of the skin.
Resistant to treatment; occurring in severe form, and frequently fatal; tending to become worse and lead to an ingravescent course; in the case of a neoplasm, having the property of uncontrollable growth and dissemination, or recurrence after removal, or both.
Dark brown to black polymers that normally occur in the skin, hair, pigmented coat of the reina, and inconstantly in the medulla and zona reticularis of the adrenal gland. The material may be formed in vitro or biologically by oxidation of tyrosine or tryptophan.
Pigment cell of the skin; melanocentrocyte; a cell located at the dermoepidermal junction having branching processes by means of which melanosomes are transferred to epidermal cells, resulting in pigmentation.
A malignant neoplasm derived from cells that are capable of forming melanin; may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. In the early phases, the lesion is characterized by proliferation of cells at the dermal-epidermal junction, and the neoplastic cells soon invade adjacent tissue extensively. The cells vary in amount and pigmentation of cytoplasm; the nuclei are relatively large and frequently bizarre in shape, with prominent acidophilic nucleoli; mitotic figures tend to be numerous.
Birthmark; a circumscribed malformation of the skin, especially if colored by hyperpigmentation or increased vascularity; it may be predominantly epidermal, adnexal, melanocytic, or mesodermal, or a compound overgrowth of these tissues. A benign localized overgrowth of malanocytes arising in the skin early in life.
Pigmentation of skin innervated by lateral branches of the supraclavicular nerve and the lateral cutaneous nerve of the arm.
Acne rosacea; acne erythematosa; vascular and follicular dilation involving the nose and contiguous portions of cheeks: may vary from very mild but persistent erytherma to extensive hyperplasia of the sebaceous glands with deep-seated papules and pustules of the affected erythematous sites.
Dermatosclerosis; sclerosis cutanea; sclerosis corii; hidebound or skinbound disease; thickening of the skin caused by swelling and thickening of fibrous tissue, with eventual atrophy of the epidermis; a manifestation of progressive systemic sclerosis.
Induration or hardening of chronic inflammatory origin; especially iduration of nervous and other structures by a hyperplasia of the interstitial fibrous or glial connective tissue.
A malignant neoplasm that is derived from stratified squamous epithelium, but that may also occur in sites where glandular or columnar epithelium is normally present; variable amounts of keratin are formed, in relation to the degree of differentiation, and, if the keratin is not on the surface, it accumulates in the neoplasm as a "keratin pearl;" in instances in which the cells are well differentiated, intercellular bridges may be observed between adjacent cells.
Dilation of the previously existing small or terminal vessels of a part.
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